Rempen A, Caffier H
Universitäts-Frauenklinik Würzburg.
Geburtshilfe Frauenheilkd. 1991 Apr;51(4):272-5. doi: 10.1055/s-2007-1023718.
The concentration of total cathepsin D, which is regarded as an additional prognostic factor, was measured in 87 patients with primary breast cancer by a radioimmunoassay in tumour cytosol. The distribution of values was approximately log normal with a median value of 49 pmol/mg protein. Relating the level of cathepsin D to other prognostic factors, no significant association to the patients' age, menopausal status, tumour size, axillary lymph node involvement, distant metastases, type of tumour, histological grading or hormone receptor status could be established. Therefore, cathepsin D seems to be independent from other established prognostic criteria, which is a prerequisite for this protease to be useful as an additional prognostic marker.
通过放射免疫分析法测定了87例原发性乳腺癌患者肿瘤细胞溶质中总组织蛋白酶D的浓度，总组织蛋白酶D被视为一种额外的预后因素。其值的分布近似对数正态分布，中位数为49 pmol/mg蛋白质。将组织蛋白酶D水平与其他预后因素相关联后发现，无法确定其与患者年龄、绝经状态、肿瘤大小、腋窝淋巴结受累情况、远处转移、肿瘤类型、组织学分级或激素受体状态之间存在显著关联。因此，组织蛋白酶D似乎独立于其他既定的预后标准，这是这种蛋白酶作为额外预后标志物发挥作用的一个先决条件。
