Romain S, Muracciole X, Varette I, Bressac C, Brandone H, Martin P M
Laboratoire d'oncologie biologique-biopathologie tissulaire, faculté de médecine de Marseille-secteur nord, France.
Bull Cancer. 1990;77(5):439-47.
The total amount of cathepsin-D (mature forms and pro-enzyme especially) in the cytosol of 88 breast cancers including 85 primary cancers and 11 axillary lymph node metastasis was measured by way of immuno-radiometric assay. Maximum follow-up is 58 months. Cathepsin-D was found to be independent of clinical and biological parameters including axillary lymph node involvement and oestradiol receptors (RE). Univariate analysis has pointed out a significant linkage between overall survival and cathepsin-D, using a cut-off level of 30 pmol/mg protein which is the most discriminating value. Cathepsin-D appeared to be particularly useful in lymph-node-positive and RE-negative patients but it was not significant in the node-negative population. Multivariate analysis of the overall survival (Cox model) revealed that it was strongly related to oestradiol receptor, lymph node involvement and cathepsin-D.
采用免疫放射分析方法测定了88例乳腺癌（包括85例原发性癌和11例腋窝淋巴结转移癌）细胞溶质中组织蛋白酶D（尤其是成熟形式和酶原）的总量。最长随访时间为58个月。发现组织蛋白酶D与包括腋窝淋巴结受累情况和雌二醇受体（RE）在内的临床和生物学参数无关。单因素分析指出，以30 pmol/mg蛋白质作为最具区分价值的临界值时，总生存期与组织蛋白酶D之间存在显著关联。组织蛋白酶D在淋巴结阳性和RE阴性患者中似乎特别有用，但在淋巴结阴性人群中并不显著。总生存期的多因素分析（Cox模型）显示，它与雌二醇受体、淋巴结受累情况和组织蛋白酶D密切相关。
