Zhao Jian-jun, Liu Yong, Chen Xin-lin, Liu Jian-xin, Tian Ying-fang, Zhang Peng-bo, Kang Qian-yan, Qiu Fen
Research Center for Neuroscience, Department of Anatomy, Histology and Embryology, School of Medicine of Xi'an Jiaotong University, Xi'an 710061, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Feb;26(2):174-6.
To investigate the effects of citicoline on spatial learning and memory of rats after focal cerebral ischemia.
The rats were randomly divided into sham-operation group, ischemia control group and citicoline group. In the later two groups, focal cerebral ischemia model was established by introducing an intraluminal filament into the left middle cerebral artery, and citicoline (500 mg/kg) or 0.9% NaCl was administered intraperitoneally once a day for 2 weeks after the operation. The rats in the sham-operation group were not subjected to middle cerebral artery occlusion (MCAO) with intraluminal filament. The spatial learning and memory functions of the rats were evaluated by Morris water maze test 15 days after MCAO for 5 days.
The rats in ischemia control group exhibited serious spatial learning and memory deficits in both place navigation test and spatial probe test. In the former test, the mean escape latency of citicoline-treated rats were significantly shorter than that of ischemia control rats (P<0.01), and in the latter test significant diffidence was noted between citicoline and ischemia control groups in the percentage time spent in the former platform quadrant and frequency of crossing the former platform (P<0.05).
Citicoline can improve the spatial learning and memory function of rats after focal cerebral ischemia.
探讨胞磷胆碱对局灶性脑缺血大鼠空间学习和记忆的影响。
将大鼠随机分为假手术组、缺血对照组和胞磷胆碱组。后两组采用线栓法插入左侧大脑中动脉建立局灶性脑缺血模型，术后每天腹腔注射胞磷胆碱（500mg/kg）或0.9%氯化钠，连续2周。假手术组大鼠不进行线栓法大脑中动脉闭塞（MCAO）。MCAO 5天后15天，通过 Morris 水迷宫试验评估大鼠的空间学习和记忆功能，共进行5天。
缺血对照组大鼠在定位航行试验和空间探索试验中均表现出严重的空间学习和记忆缺陷。在前一项试验中，胞磷胆碱治疗组大鼠的平均逃避潜伏期明显短于缺血对照组大鼠（P<0.01），在后一项试验中，胞磷胆碱组与缺血对照组在前平台象限停留时间百分比和穿越前平台频率方面存在显著差异（P<0.05）。
胞磷胆碱可改善局灶性脑缺血大鼠的空间学习和记忆功能。
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