Lee Se-Hoon, Ahn Yong Chan, Kim Won Seog, Ko Young H, Kim Kihyun, Park Keunchil
Haematologica. 2006 Mar;91(3):427-8. Epub 2006 Feb 17.
We treated 17 patients with localized, nasal NK/T-cell lymphoma with two cycles of dose-intense CHOP (DI-CHOP) and early involved field radiation (IFRT). Sixteen out of 17 patients were evaluable for response. After two cycles of DICHOP, nine patients achieved complete remission (CR) (53%) and six had partial remissions (35%). After IFRT, 13 patients achieved CR (CR rate 76%; 95% CI, 56%-96%). The 3-year progression-free and overall survival rates were 56%, and 67%, respectively. This study shows that anthracycline-based chemotherapy seems to be ineffective in decreasing systemic failure even when administered at maximal dose intensity.
我们对17例局限性鼻腔NK/T细胞淋巴瘤患者进行了两个周期的剂量密集CHOP（DI-CHOP）化疗及早期受累野放疗（IFRT）。17例患者中有16例可评估疗效。两个周期的DICHOP化疗后，9例患者达到完全缓解（CR）（53%），6例部分缓解（35%）。IFRT后，13例患者达到CR（CR率76%；95%CI，56%-96%）。3年无进展生存率和总生存率分别为56%和67%。本研究表明，即使以最大剂量强度给药，蒽环类化疗在降低全身衰竭方面似乎无效。
