使用指长比作为围产期雄激素作用的标志物。
The use of digit ratios as markers for perinatal androgen action.
作者信息
McIntyre Matthew H
机构信息
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
出版信息
Reprod Biol Endocrinol. 2006 Feb 26;4:10. doi: 10.1186/1477-7827-4-10.
Abstract
Since the ratio of the second-to-fourth finger length was first proposed as a marker for prenatal androgen action in 1998, over 100 studies have been published that have either further tested the association between the digit ratio and prenatal androgens, or employed digit ratios as a marker to investigate the association between prenatal androgens and a variety of outcomes, including behavior, fertility, and disease risks. Despite the clear demand for an adult marker of prenatal androgen action and increased use of digit ratios as such a marker, its validity remains controversial. This review (1) evaluates current evidence for the relationship between digit ratios and prenatal androgens (using experimentation with animal models, amniotic testosterone, and congenital adrenal hyperplasia case-control studies), (2) describes opportunities for future validation tests, and (3) compares the potential advantages and disadvantages of digit ratio measures with more established methods for studying the effects of prenatal androgens.
摘要
自1998年首次提出将食指与无名指长度之比作为产前雄激素作用的标志物以来，已发表了100多项研究，这些研究要么进一步检验了指长比与产前雄激素之间的关联，要么采用指长比作为标志物来研究产前雄激素与包括行为、生育能力和疾病风险在内的各种结果之间的关联。尽管对产前雄激素作用的成人标志物有明确需求，且指长比作为此类标志物的使用越来越多，但其有效性仍存在争议。本综述：（1）评估指长比与产前雄激素之间关系的现有证据（使用动物模型实验、羊水睾酮和先天性肾上腺皮质增生病例对照研究）；（2）描述未来验证测试的机会；（3）比较指长比测量方法与研究产前雄激素作用的更成熟方法的潜在优缺点。
相似文献
1
The use of digit ratios as markers for perinatal androgen action.使用指长比作为围产期雄激素作用的标志物。
Reprod Biol Endocrinol. 2006 Feb 26;4:10. doi: 10.1186/1477-7827-4-10.
2
3
Is early postnatal growth velocity, a proxy of minipubertal androgen action, related to adult second-to-fourth digit (2D:4D) ratios in men? A test in Cebu, Philippines.出生后早期生长速度作为小青春期雄激素作用的一个指标，与男性成年后的食指与无名指比例（2D:4D）有关吗？在菲律宾宿务进行的一项测试。
Am J Hum Biol. 2017 Nov;29(6). doi: 10.1002/ajhb.23047. Epub 2017 Jul 31.
4
Fingers as a marker of prenatal androgen exposure.手指作为产前雄激素暴露的标志。
Endocrinology. 2009 Nov;150(11):5119-24. doi: 10.1210/en.2009-0774. Epub 2009 Oct 9.
5
Do sex differences in CEOAEs and 2D:4D ratios reflect androgen exposure? A study in women with complete androgen insensitivity syndrome.女性完全型雄激素不敏感综合征中 CEOAEs 和 2D:4D 比值的性别差异是否反映了雄激素暴露？一项研究。
Biol Sex Differ. 2017 Apr 12;8:11. doi: 10.1186/s13293-017-0132-z. eCollection 2017.
6
No association between two candidate markers of prenatal sex hormones: digit ratios (2D:4D and other) and finger-ridge counts.没有证据表明两个候选产前性激素标志物（2D:4D 和其他）与指纹计数之间存在关联。
Dev Psychobiol. 2011 Jan;53(1):69-78. doi: 10.1002/dev.20488.
7
Minireview: Organizational hypothesis: instances of the fingerpost.综述：组织假说：指状骨实例。
Endocrinology. 2010 Sep;151(9):4116-22. doi: 10.1210/en.2010-0041. Epub 2010 Jul 14.
8
Adult digit ratio (2D:4D) is not related to umbilical cord androgen or estrogen concentrations, their ratios or net bioactivity.成人手指比例（2D:4D）与脐带雄激素或雌激素浓度、它们的比例或净生物活性无关。
Early Hum Dev. 2015 Feb;91(2):111-7. doi: 10.1016/j.earlhumdev.2014.12.011. Epub 2015 Jan 13.
9
Second to fourth digit ratio confirms aggressive tendencies in patients with boxers fractures.第二到第四指骨比率可证实拳击手骨折患者的攻击倾向。
Injury. 2013 Nov;44(11):1636-9. doi: 10.1016/j.injury.2013.07.018. Epub 2013 Aug 6.
10
New studies of second and fourth digit ratio as a morphogenetic trait in subjects with congenital adrenal hyperplasia.新研究显示，第二和第四指比率可作为先天性肾上腺皮质增生症患者的一种形态发生特征。
Am J Hum Biol. 2014 Jul-Aug;26(4):559-61. doi: 10.1002/ajhb.22545. Epub 2014 Mar 25.
引用本文的文献
1
Investigating the relationship between prenatal androgen exposure and sleep quality: a comprehensive study using anthropometric measurements, questionnaires, actigraphy, and polysomnography.探究产前雄激素暴露与睡眠质量之间的关系：一项综合研究，采用人体测量、问卷调查、活动记录仪和多导睡眠图技术。
Front Endocrinol (Lausanne). 2025 Jan 16;15:1480963. doi: 10.3389/fendo.2024.1480963. eCollection 2024.
2
Evaluation of Digit Ratios in Youth With Polycystic Ovary Syndrome.多囊卵巢综合征青年女性手指比例评估
Cureus. 2024 Aug 19;16(8):e67168. doi: 10.7759/cureus.67168. eCollection 2024 Aug.
3
The Impact of Endometriosis on Intracellular Calcium Levels, Cyclic Dependent Kinase 1 (Cdk1) Expression, and Cyclin B Expression in Post-Ovulation Oocytes of Mice Model.子宫内膜异位症对小鼠模型排卵后卵母细胞内钙水平、细胞周期蛋白依赖性激酶1（Cdk1）表达及细胞周期蛋白B表达的影响。
J Reprod Infertil. 2023 Oct-Dec;24(4):232-239. doi: 10.18502/jri.v24i4.14150.
4
The association of prenatal amniotic sex hormones and digit ratio (2D:4D) in children aged 5 to 70 months: A longitudinal study.5 至 70 月龄儿童产前羊水中性激素与指长比（2D:4D）的相关性：一项纵向研究。
PLoS One. 2023 Mar 23;18(3):e0282253. doi: 10.1371/journal.pone.0282253. eCollection 2023.
5
The ratio of 2nd to 4th digit length and reproductive function of infertile male patients.不育男性患者第二与第四指长度之比及生殖功能
Reprod Med Biol. 2023 Feb 8;22(1):e12500. doi: 10.1002/rmb2.12500. eCollection 2023 Jan-Dec.
6
Forensic application of foot dimensions in ethnic differentiation among Ghanaians.加纳人族群区分中的足部尺寸的法医学应用。
Acta Biomed. 2023 Feb 13;94(1):e2023026. doi: 10.23750/abm.v94i1.13422.
7
Associations of maternal anthropometrics with newborn anogenital distance and the 2:4 digit ratio.母亲人体测量学与新生儿肛门生殖器距离和 2:4 指长比的关联。
Hum Reprod. 2022 Aug 25;37(9):2154-2166. doi: 10.1093/humrep/deac143.
8
Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification.解构综合征：多囊卵巢综合征发病机制和分类的基因组学见解。
Endocr Rev. 2022 Nov 25;43(6):927-965. doi: 10.1210/endrev/bnac001.
9
Second to fourth (2D:4D) digit ratio and their relationships among a mother and child population in Ghana.加纳母婴人群的第二至第四指（2D:4D）比率及其关系。
Sci Rep. 2021 Jun 22;11(1):13028. doi: 10.1038/s41598-021-92358-x.
10
Associations between fetal testosterone and pro-social tendencies, anxiety and autistic symptoms in Williams syndrome: a preliminary study.威廉姆斯综合征中胎儿睾酮与亲社会倾向、焦虑及自闭症症状之间的关联：一项初步研究。
Int J Dev Disabil. 2017 Sep 27;65(2):82-88. doi: 10.1080/20473869.2017.1376163.
本文引用的文献
1
Quantitative genetics and behavioural correlates of digit ratio in the zebra finch.斑胸草雀指长比的数量遗传学及行为相关性
Proc Biol Sci. 2005 Dec 22;272(1581):2641-9. doi: 10.1098/rspb.2005.3264.
2
Sex dimorphism in digital formulae of children.儿童手指比例的性别差异。
Am J Phys Anthropol. 2006 Jan;129(1):143-50. doi: 10.1002/ajpa.20240.
3
Finger-length ratios show evidence of prenatal hormone-transfer between opposite-sex twins.手指长度比例显示了异性双胞胎之间存在产前激素转移的证据。
Horm Behav. 2006 Mar;49(3):315-9. doi: 10.1016/j.yhbeh.2005.08.003. Epub 2005 Sep 6.
4
In vivo models of prostate cancer metastasis to bone.前列腺癌骨转移的体内模型。
J Urol. 2005 Sep;174(3):820-6. doi: 10.1097/01.ju.0000169133.82167.aa.
5
The development of sex differences in digital formula from infancy in the Fels Longitudinal Study.费尔斯纵向研究中婴儿期手指长度比例性别差异的发展。
Proc Biol Sci. 2005 Jul 22;272(1571):1473-9. doi: 10.1098/rspb.2005.3100.
6
Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk.不同种族的妊娠激素浓度：对后期癌症风险的影响。
Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1514-20. doi: 10.1158/1055-9965.EPI-04-0869.
7
Maternal serum steroid levels are unrelated to fetal sex: a study in twin pregnancies.母血清类固醇水平与胎儿性别无关：一项双胎妊娠研究
Twin Res Hum Genet. 2005 Apr;8(2):173-7. doi: 10.1375/1832427053738764.
8
Experimental manipulation of yolk testosterone affects digit length ratios in the ring-necked pheasant (Phasianus colchicus).对环颈雉（雉鸡）卵黄睾酮进行实验性操控会影响其指长比。
Horm Behav. 2005 Sep;48(3):342-6. doi: 10.1016/j.yhbeh.2005.03.007.
9
Hormonal influences on sexually differentiated behavior in nonhuman primates.激素对非人灵长类动物性别分化行为的影响。
Front Neuroendocrinol. 2005 Apr;26(1):7-26. doi: 10.1016/j.yfrne.2005.02.001.
10
Maternal hormone levels among populations at high and low risk of testicular germ cell cancer.睾丸生殖细胞癌高风险和低风险人群中的母体激素水平。
Br J Cancer. 2005 May 9;92(9):1787-93. doi: 10.1038/sj.bjc.6602545.
Zotero 插件