小牛胸腺拓扑异构酶I的两种分子形式对鸡αA-珠蛋白基因和人c-Ha-ras基因的特异性切割
Specific cleavage of chicken alpha A-globin and human c-Ha-ras genes by two molecular forms of calf thymus topoisomerase I.
作者信息
Bronstein I B, Gromova I I, Razin S V
机构信息
Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
出版信息
Mol Cell Biochem. 1991 Mar 13;101(2):115-24. doi: 10.1007/BF00229529.
PMID:1650425
Abstract
Two molecular forms of topoisomerase I differing in size and sensitivity to camptothecin were isolated from calf thymus. Mapping of topo I cleavage sites of the cloned chicken alpha A-globin and human c-Ha-ras genes was carried out. Camptothecin was shown to affect site specificity of the topoisomerases.
摘要
从小牛胸腺中分离出了两种大小不同且对喜树碱敏感性各异的拓扑异构酶I分子形式。对克隆的鸡αA-珠蛋白和人c-Ha-ras基因的拓扑异构酶I切割位点进行了定位。结果表明，喜树碱会影响拓扑异构酶的位点特异性。
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