Dessi F, Represa A, Ben-Ari Y
INSERM U29, Paris, France.
Neuroscience. 1991;42(1):151-7. doi: 10.1016/0306-4522(91)90155-h.
In the rat, neonatal irradiation produces a destruction of dentate granule cells and prevents the development of the mossy fibre-CA3 pyramidal cell synapse. The developmental increase of high affinity kainate binding sites in the stratum lucidum was reduced on the irradiated side as compared with the control side. This suggests that a proportion of high affinity kainate binding sites is associated with mossy fibres. In contrast, the developmental profile of N-methyl-D-aspartate binding sites, which are associated with associational and commissural synapses in CA3, was not affected by irradiation. The role that afferent fibres may play in the development of pyramidal cells is discussed in connection with the modulatory effects of glutamate receptors on the development of neurons.
在大鼠中，新生期照射会导致齿状颗粒细胞的破坏，并阻止苔藓纤维-CA3锥体细胞突触的发育。与对照侧相比，照射侧透明层中高亲和力红藻氨酸结合位点的发育性增加减少。这表明一部分高亲和力红藻氨酸结合位点与苔藓纤维相关。相反，与CA3区联合和连合突触相关的N-甲基-D-天冬氨酸结合位点的发育情况不受照射影响。结合谷氨酸受体对神经元发育的调节作用，讨论了传入纤维在锥体细胞发育中可能发挥的作用。
