Albin R L, Makowiec R L, Hollingsworth Z, Dure L S, Penney J B, Young A B
Department of Neurology, University of Michigan, Ann Arbor.
Neurosci Lett. 1990 Oct 2;118(1):112-5. doi: 10.1016/0304-3940(90)90261-7.
We used receptor autoradiography to determine the distribution of excitatory amino acid (EAA) binding site subtypes in the periaqueductal gray (PAG) of the rat. N-Methyl-D-aspartate (NMDA), kainate, quisqualate-ionotropic, and quisqualate-metabotropic binding sites were all present in the PAG. Distribution was inhomogeneous with greatest density of all binding site subtypes in the dorsolateral subdivision and lowest density in the ventrolateral subdivision. Relative to regions of brain with high densities of EAA binding site subtypes, quisqualate-metabotropic binding sites had the highest relative density and NMDA binding sites the least. The presence of all subtypes of EAA binding sites in the PAG suggests that EAA action within the PAG is likely to be complex.
我们采用受体放射自显影术来确定大鼠中脑导水管周围灰质（PAG）中兴奋性氨基酸（EAA）结合位点亚型的分布。N-甲基-D-天冬氨酸（NMDA）、 kainate、离子型谷氨酸盐和代谢型谷氨酸盐结合位点均存在于PAG中。分布不均匀，所有结合位点亚型在背外侧亚区密度最高，在腹外侧亚区密度最低。相对于EAA结合位点亚型高密度的脑区，代谢型谷氨酸盐结合位点的相对密度最高，NMDA结合位点的相对密度最低。PAG中EAA结合位点所有亚型的存在表明，EAA在PAG内的作用可能很复杂。
