Gref Ruxandra, Amiel Catherine, Molinard Karine, Daoud-Mahammed Samia, Sébille Bernard, Gillet Brigitte, Beloeil Jean-Claude, Ringard Catherine, Rosilio Véronique, Poupaert Jaques, Couvreur Patrick
School of Pharmacy, Université Paris Sud, UMR CNRS 8612, 5 Rue J. B. Clément, 92290 Châtenay Malabry, France.
J Control Release. 2006 Apr 10;111(3):316-24. doi: 10.1016/j.jconrel.2005.12.025. Epub 2006 Feb 28.
We show here, for the first time, that two neutral polymers may completely associate together in water to spontaneously form supramolecular nanoassemblies (nanogels) of spherical shape. The cohesion of these stable structures of about 200 nm is based upon a "lock and key" mechanism: inclusion complexes are formed between the hydrophobic alkyl chains grafted on a polysaccharide (dextran) and the molecular cavities contained in a poly-cyclodextrin polymer. Production yields reached 95%. It was established that all the alkyl chains were included within the cyclodextrins' cavities in these nanoassemblies. The multivalent character of the interactions between the two polymers ensures the stability of the nanoassemblies. Moreover, empty cyclodextrin units remained accessible for the inclusion of compounds of interest such as benzophenon or tamoxifen.
我们首次在此表明，两种中性聚合物在水中可能完全缔合在一起，自发形成球形超分子纳米聚集体（纳米凝胶）。这些约200纳米的稳定结构的凝聚基于一种“锁钥”机制：接枝在多糖（右旋糖酐）上的疏水烷基链与聚环糊精聚合物中含有的分子腔之间形成包合物。产率达到了95%。已确定在这些纳米聚集体中所有烷基链都包含在环糊精的腔内。两种聚合物之间相互作用的多价特性确保了纳米聚集体的稳定性。此外，空的环糊精单元对于包合诸如二苯甲酮或他莫昔芬等感兴趣的化合物仍然是可利用的。
