Systèmes Polymères Complexes, ICMPE, UMR 7182 CNRS-UPEC, 2 rue Henri Dunant, 94320 Thiais, France.
Biomacromolecules. 2012 Feb 13;13(2):528-34. doi: 10.1021/bm201608n. Epub 2012 Jan 31.
The main goal of this work was to develop two strategies for stabilization of nanoassemblies made of β-cyclodextrin polymer and amphiphilic dextran associated through host-guest complexes. The first strategy was to coat the nanoassemblies with a dextran derivative bearing adamantyl anchoring groups and hydrophilic poly(ethylene oxide-co-propylene oxide) side chains to increase the steric repulsion between the nanoassemblies. The second strategy developed was to post-reticulate the nanoassemblies upon UV irradiation. Photo-cross-linkable nanoassemblies have been prepared from new host or guest polymers bearing allylether or methacrylate groups. The modified nanoassemblies have been characterized by dynamic light scattering as a function of time and for various salt and competitor concentrations. The results of the first strategy show an improvement of shelf stability and resistance at relatively low concentrations of competitors. The second strategy is the most efficient in providing good shelf stability, much larger than with the first strategy, together with a large resistance to dissociation in presence of competitors.
这项工作的主要目标是开发两种策略来稳定由β-环糊精聚合物和通过主客体配合物结合的两亲性葡聚糖组成的纳米组装体。第一种策略是用带有金刚烷基锚固基团和亲水性聚（氧化乙烯-氧化丙烯）侧链的葡聚糖衍生物来包覆纳米组装体，以增加纳米组装体之间的空间排斥力。第二种策略是在 UV 照射下对纳米组装体进行后交联。通过带有烯丙基醚或甲基丙烯酰基的新型主体或客体聚合物制备了光交联纳米组装体。通过动态光散射研究了修饰后的纳米组装体随时间的变化以及在不同盐和竞争物浓度下的性质。第一种策略的结果表明，在相对较低的竞争物浓度下，货架稳定性和抗分解能力得到了提高。第二种策略在提供良好的货架稳定性方面最为有效，其稳定性远大于第一种策略，并且在存在竞争物时具有较大的抗离解能力。
