Shahar E M, Hwang P A, Niesen C E, Murphy E G
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Pediatrics. 1991 Aug;88(2):276-9.
A poliomyelitis-like paralytic disease during recovery from an attack of bronchial asthma is described in two young children. They presented at the age of 13 and 22 months, respectively, with acute flaccid paralysis of one or both lower limbs and preserved sensation. Cerebrospinal fluid examinations revealed mild protein elevation in both and pleocytosis in the second infant. Enteroviruses were isolated in a nasal swab and stools of the second patient. Acute onset of flaccid paralysis with absent motor action potential and normal sensory responses, detected by electrophysiologic studies, are highly suggestive of motor anterior horn cell disease in these infants. A multifactorial setup of immune suppression, stress, and neurotoxic drugs during an acute bronchial asthma attack triggered by a viral disease may render the patient vulnerable to viral invasion of the anterior horn cell with enteroviruses other than poliovirus. The overall experience of 22 patients with this serious complication is reviewed.
两名幼儿在支气管哮喘发作恢复期间出现了类似小儿麻痹症的麻痹性疾病。他们分别在13个月和22个月大时出现一个或两个下肢急性弛缓性麻痹且感觉保留。脑脊液检查显示两人均有轻度蛋白升高，第二名婴儿有细胞增多。在第二名患者的鼻拭子和粪便中分离出肠道病毒。电生理研究检测到的急性弛缓性麻痹伴运动动作电位消失和感觉反应正常，强烈提示这些婴儿患有运动性前角细胞疾病。由病毒疾病引发的急性支气管哮喘发作期间，免疫抑制、压力和神经毒性药物的多因素组合可能使患者易受除脊髓灰质炎病毒外的肠道病毒对前角细胞的侵袭。本文回顾了22例患有这种严重并发症患者的总体情况。
