Yu Jianming, Buckler Edward S
Institute for Genomic Diversity and United States Department of Agriculture--Agricultural Research Service, Ithaca, NY 14853, USA.
Curr Opin Biotechnol. 2006 Apr;17(2):155-60. doi: 10.1016/j.copbio.2006.02.003. Epub 2006 Feb 28.
Association mapping, a high-resolution method for mapping quantitative trait loci based on linkage disequilibrium, holds great promise for the dissection of complex genetic traits. The recent assembly and characterization of maize association mapping panels, development of improved statistical methods, and successful association of candidate genes have begun to realize the power of candidate-gene association mapping. Although the complexity of the maize genome poses several significant challenges to the application of association mapping, the ongoing genome sequencing project will ultimately allow for a thorough genome-wide examination of nucleotide polymorphism-trait association.
关联分析是一种基于连锁不平衡来定位数量性状基因座的高分辨率方法，在剖析复杂遗传性状方面具有巨大潜力。近期玉米关联分析群体的构建与特征分析、改进统计方法的开发以及候选基因的成功关联，已开始展现出候选基因关联分析的强大威力。尽管玉米基因组的复杂性给关联分析的应用带来了若干重大挑战，但正在进行的基因组测序项目最终将能够对核苷酸多态性与性状的关联进行全面的全基因组检测。
