死亡之吻：却被另一种自然杀伤细胞的近距离接触打断。

The kiss of death: interrupted by NK-cell close encounters of another kind.

作者信息

Wahl Sharon M, Wen Jie, Moutsopoulos Niki M

机构信息

Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892-4352, USA.

出版信息

Trends Immunol. 2006 Apr;27(4):161-4. doi: 10.1016/j.it.2006.02.002. Epub 2006 Feb 28.

DOI:10.1016/j.it.2006.02.002

PMID:16504582

Abstract

An intimate but deadly encounter between natural killer (NK) cells and transformed cells results in the delivery of cytotoxic molecules into tumor cells. New evidence reveals another intimate association, this time between NK cells and regulatory T cells, but this encounter opposes NK-cell tumoricidal activity. Through a contact-dependent mechanism involving transforming growth factor-beta, regulatory T cells provide an escape mechanism from NK-cell-mediated tumor surveillance.

摘要

自然杀伤（NK）细胞与转化细胞之间亲密却致命的相遇会导致细胞毒性分子被输送到肿瘤细胞中。新证据揭示了另一种亲密关联，这次是在NK细胞和调节性T细胞之间，但这种相遇会对抗NK细胞的杀肿瘤活性。通过一种涉及转化生长因子-β的接触依赖性机制，调节性T细胞提供了一种逃避NK细胞介导的肿瘤监视的机制。