Lukas Jiri, Bohr Vilhelm A, Halazonetis Thanos D
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
DNA Repair (Amst). 2006 May 10;5(5):591-601. doi: 10.1016/j.dnarep.2006.01.006. Epub 2006 Feb 28.
The response of cells to DNA damage is critical for maintaining genomic integrity and for preventing cancer development. Current advances in our understanding of the response of cells to DNA double-strand breaks and to stalled DNA replication forks and the relationship of these responses to human disease were discussed at the 52nd Benzon Symposium in Denmark, Copenhagen. Here we review the novel findings that were presented at this Symposium and the current state of the field.
细胞对DNA损伤的反应对于维持基因组完整性和预防癌症发展至关重要。在丹麦哥本哈根举行的第52届本松研讨会上，讨论了我们目前对细胞对DNA双链断裂和停滞的DNA复制叉的反应以及这些反应与人类疾病的关系的理解进展。在此，我们回顾本次研讨会上提出的新发现以及该领域的现状。
