Masura Jozef, Tittel Peter, Gavora Pavol, Podnar Tomaz
Children's Cardiac Center, University Children's Hospital, Limbova 1, Kramare, 83 340 Bratislava, Slovakia.
Am Heart J. 2006 Mar;151(3):755.e7-755.e10. doi: 10.1016/j.ahj.2005.12.010.
Immediate-, short-, and intermediate-term results of percutaneous patent ductus arteriosus (PDA) closure using Amplatzer duct occluders are excellent. However, long-term results have not yet been reported to date.
Between September 1996 and April 2002, 64 consecutive patients having isolated PDA with minimal diameter of > or =2 mm underwent percutaneous closure using Amplatzer duct occluders. All patients were included in this study and have been followed up until September 2005.
Patients have been followed up from 40 to 108 months (median 58 months). The mean PDA diameter was 3.5 +/- 1.6 mm. There were no deaths or significant complications during the study period. At a 1-month follow-up, all PDA were completely closed and remained closed thereafter.
Since the initial clinical experience in September 1996, the Amplatzer duct occluder has been proven as a safe and effective device for transcatheter PDA closure. Based on our experience, we believe that in patients having completely closed PDA with laminar blood flow pattern in the descending thoracic aorta and left pulmonary artery at a 1-year follow-up, there is no need for further evaluations. In contrast, few remaining patients need a careful follow-up until a complete normalization of all findings.
使用Amplatzer动脉导管封堵器经皮闭合动脉导管未闭（PDA）的近期、短期和中期结果均非常理想。然而，迄今为止尚未有长期结果的报道。
1996年9月至2002年4月期间，64例孤立性PDA最小直径≥2mm的连续患者接受了使用Amplatzer动脉导管封堵器的经皮闭合术。所有患者均纳入本研究，并随访至2005年9月。
患者的随访时间为40至108个月（中位时间58个月）。PDA的平均直径为3.5±1.6mm。研究期间无死亡或严重并发症发生。在1个月的随访时，所有PDA均完全闭合，此后一直保持闭合状态。
自1996年9月首次临床应用以来，Amplatzer动脉导管封堵器已被证明是一种安全有效的经导管闭合PDA的装置。根据我们的经验，我们认为，在1年随访时PDA已完全闭合且降主动脉和左肺动脉血流呈层流模式的患者中，无需进一步评估。相反，少数剩余患者需要仔细随访直至所有检查结果完全正常。
