早期肾移植受者的肾动脉阻力指数、甲状腺激素及甲状腺体积

Renal artery resistance index, thyroid hormones, and thyroid volume in the early kidney transplants recipients.

作者信息

Łebkowska U, Małyszko J, Brzósko S, Łebkowski W, Małyszko J S, Janica J, Kowalewski R, Gacko M, Myśliwiec M, Walecki J

机构信息

Department of Radiology, Białystok Medical University, ul. M. Skłodowskiej-Curie 24a, 150276 Białystok, Poland.

出版信息

Transplant Proc. 2006 Jan-Feb;38(1):62-5. doi: 10.1016/j.transproceed.2005.12.030.

DOI:10.1016/j.transproceed.2005.12.030

PMID:16504665

Abstract

BACKGROUND

Thyroid hormones could affect renal function, and, on the other hand, renal dysfunction may affect thyroid function. Disturbances of concentrations of thyroid hormones are often associated with thyroid gland enlargement. The aim of the study was to assess the function and morphology of the thyroid (volume and hormones concentration) and kidney function after transplantation (creatinine concentration and resistance index [RI] of transplant artery).

MATERIAL AND METHODS

The group included 13 females, 19 males; aged 19-69 years, mean 44.75 +/- 14.8 years after transplantation with stable graft function. Thyroid volume, renal artery RI, creatinine concentration, and concentrations of T3, rT3, FT3, FT4, and TSH were estimated the day before surgery, and at 1, 3, 6, and 10 days after transplantation.

RESULTS

The statistical analysis revealed a negative correlation between delta RI (difference between RI at 3 and 6 days after transplantation) and serum creatinine concentration, 10 days after transplantation (r = -0.63; P < 0.01). We also observed a negative correlation between creatinine serum concentration at 10 days after transplantation and delta thyroid volume (Delta Vol; r = - 0.48; p < .05), a positive correlation between delta FT4 (Delta FT4) serum concentration, and delta creatinine (Delta Crea; r = 0.73; P < .001).

CONCLUSIONS

The dynamics of RI changes in the transplant kidney artery between 3 and 6 days after transplantation may predict graft function. Together with improved kidney function at 10 days after transplantation, we observed a regression of goiter.

摘要

背景

甲状腺激素可影响肾功能，反之，肾功能障碍也可能影响甲状腺功能。甲状腺激素浓度紊乱常与甲状腺肿大有关。本研究的目的是评估甲状腺移植后的功能和形态（体积和激素浓度）以及肾功能（肌酐浓度和移植肾动脉阻力指数[RI]）。

材料与方法

该组包括13名女性和19名男性；年龄在19 - 69岁之间，移植后平均44.75±14.8岁，移植肾功能稳定。在手术前一天以及移植后1天、3天、6天和10天评估甲状腺体积、肾动脉RI、肌酐浓度以及T3、反T3、游离T3、游离T4和促甲状腺激素（TSH）的浓度。

结果

统计分析显示，移植后10天，δRI（移植后3天和6天RI的差值）与血清肌酐浓度呈负相关（r = -0.63；P < 0.01）。我们还观察到移植后10天血清肌酐浓度与甲状腺体积变化量（ΔVol；r = - 0.48；p < 0.05）呈负相关，血清游离T4变化量（ΔFT4）与肌酐变化量（ΔCrea；r = 0.73；P < 0.001）呈正相关。