日本社区获得性肺炎患儿非典型病原体的前瞻性监测。
Prospective surveillance for atypical pathogens in children with community-acquired pneumonia in Japan.
作者信息
Bamba Masahiro, Jozaki Keiji, Sugaya Norio, Tamai Shinya, Ishihara Jun, Kori Takeo, Shiro Hiroyuki, Takeuchi Yoshinao, Cho Hideo, Nakao Ayumi, Okano Yuji, Kimura Kazuhiro, Komiyama Osamu, Nonoyama Masato, Kobayashi Intetsu, Kato Tatsuo, Sunakawa Keisuke
机构信息
Department of Pediatrics, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori, Yokosuka-shi, Kanagawa 238-8558, Japan.
出版信息
J Infect Chemother. 2006 Feb;12(1):36-41. doi: 10.1007/s10156-005-0422-y.
A total of 141 children with community-acquired pneumonia (CAP) were studied prospectively to determine the causative microorganisms. Microbial investigations included examination of postnasal swabs, cultures, polymerase chain reaction (PCR), and serology. The atypical pathogens occurring most frequently were Mycoplasma pneumoniae (58 patients [41.1%]), Chlamydia pneumoniae (4 patients [2.8%]), and concurrent occurrence of both pathogens (1 patient [0.7%]). Patients aged under 4 years showed a relatively lower rate of atypical bacterial etiology compared with those aged 4 years or older. Major bacterial pathogens were detected in 89 patients (atypical pathogens were detected in 28 patients simultaneously), including Streptococcus pneumoniae in 34 patients, Haemophilus influenzae in 60, Moraxella catarrhalis in 48, and multiple pathogens in 42. In patients suspected of having atypical pneumonia, macrolides are recommended.
对141例社区获得性肺炎（CAP）患儿进行前瞻性研究以确定致病微生物。微生物学检查包括鼻后拭子检查、培养、聚合酶链反应（PCR）和血清学检查。最常见的非典型病原体为肺炎支原体（58例[41.1%]）、肺炎衣原体（4例[2.8%]）以及两种病原体同时存在（1例[0.7%]）。4岁以下患儿非典型细菌病因发生率相对低于4岁及以上患儿。89例患儿检测到主要细菌病原体（28例同时检测到非典型病原体），包括肺炎链球菌34例、流感嗜血杆菌60例、卡他莫拉菌48例以及多种病原体42例。对于疑似非典型肺炎的患者，推荐使用大环内酯类药物。
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