Lochindarat S, Suwanjutha S, Prapphal N, Chantarojanasiri T, Bunnag T, Deerojanawong J, Kunakorn M, Srisan P
Queen Sirikit National Institute of Child Health, Ministry of Public Health, Bangkok, Thailand.
Int J Tuberc Lung Dis. 2007 Jul;11(7):814-9.
The prevalence of community-acquired pneumonia (CAP) caused by atypical pathogens in Thai children is unknown.
To examine the prevalence of Mycoplasma pneumoniae and Chlamydophila pneumoniae infections in paediatric patients (aged 2-15 years) with CAP in three academic hospitals using standardised laboratory techniques. The characteristics of atypical pneumonia were also compared with other causes of CAP.
Diagnosis of current infection was based on a four-fold or more rise in antibody serum samples or persistently high antibody titres together with the presence of mycoplasmal or chlamydial DNA in secretions.
Of 245 patients with CAP, 17.5% of cases were caused by atypical pathogens (M. pneumoniae 14.3%, C. pneumoniae 2.8% and co-infection 0.4%). We also found atypical pathogens in young children aged 2-5 years. The clinical and laboratory findings did not distinguish atypical pneumonia from other CAPs. Segmental or lobar consolidation on chest X-rays was more common in atypical pneumonia, while dyspnoea was more prominent in other CAPs.
Our data show a high prevalence of M. pneumoniae and C. pneumoniae in Thai children with CAP, including in children aged 2-5 years.
泰国儿童由非典型病原体引起的社区获得性肺炎（CAP）的患病率尚不清楚。
采用标准化实验室技术，检测三家学术医院2至15岁CAP儿科患者中肺炎支原体和肺炎衣原体感染的患病率。还将非典型肺炎的特征与CAP的其他病因进行了比较。
当前感染的诊断基于抗体血清样本升高四倍或更多，或抗体滴度持续升高，以及分泌物中存在支原体或衣原体DNA。
在245例CAP患者中，17.5%的病例由非典型病原体引起（肺炎支原体14.3%，肺炎衣原体2.8%，合并感染0.4%）。我们还在2至5岁的幼儿中发现了非典型病原体。临床和实验室检查结果无法区分非典型肺炎和其他类型的CAP。胸部X光片上的节段性或大叶性实变在非典型肺炎中更为常见，而呼吸困难在其他类型的CAP中更为突出。
我们的数据显示，在泰国患CAP的儿童中，包括2至5岁的儿童，肺炎支原体和肺炎衣原体的患病率很高。
