Lin Z Y
Liver Cancer Research Institute, Shanghai Medical University.
Zhonghua Wai Ke Za Zhi. 1991 Feb;29(2):93-6, 141-2.
From Jan. 1961 to Dec. 1988, 188 patients with hepatocellular carcinoma had radical resection. AFP concentration of all patients turned negative after the operation or was originally negative. By the end of August 1989, 85 patients had cancer recurrence after surgery with a median of 18 months (1-106 months). Recurrence happened mostly in the first and second year postoperation. The cumulative recurrence was 35.8% in one year, 62.4% in two years, and 95.3% in 5 years. Serial measurement of serum AFP and ultrasonography were found useful for early detection of cancer recurrence. For the patients with cancer recurrence, reoperation was the treatment of choice, and 49.4% of them underwent the second resection, with normal AFP concentrations in 58.6% of the patients after surgery. The 1-, 3-, and 5-year survival rates were 50%, 27.3%, and 23.5% after the second resection, respectively. Chemotherapy combined with immunotherapy was effective to prolong the recurrence-free survival time after the primary resection.
1961年1月至1988年12月，188例肝细胞癌患者接受了根治性切除。所有患者术后甲胎蛋白（AFP）浓度均转为阴性或原本即为阴性。至1989年8月底，85例患者术后出现癌症复发，中位复发时间为18个月（1 - 106个月）。复发大多发生在术后第一年和第二年。一年累积复发率为35.8%，两年为62.4%，五年为95.3%。发现连续检测血清AFP和超声检查有助于早期发现癌症复发。对于癌症复发患者，再次手术是首选治疗方法，其中49.4%的患者接受了二次切除，术后58.6%的患者AFP浓度恢复正常。二次切除后1年、3年和5年生存率分别为50%、27.3%和23.5%。化疗联合免疫治疗可有效延长初次切除后的无复发生存时间。
