Mazzocchi G, Malendowicz L K, Andreis P G, Nussdorfer G G
Department of Anatomy, University of Padua, Italy.
Exp Clin Endocrinol. 1991 Mar;97(1):34-8. doi: 10.1055/s-0029-1211035.
Neurotensin (NT), a hypothalamic peptide which is also contained in the chromaffin granules of adrenal medullary cells, did not affect either basal or ACTH-stimulated secretory activity of isolated rat zona glomerulosa (ZG) cells. Conversely, NT was found to exert a strong dose-dependent inhibitory effect on aldosterone response of ZG cells to their two main calcium-dependent secretagogues angiotensin-II and potassium. These findings suggest that NT may interfere with the angiotensin-II- or potassium-induced activation of protein kinase C, possibly by blunting the rise in the cytosolic calcium concentration.
神经降压素（NT）是一种下丘脑肽，肾上腺髓质细胞的嗜铬颗粒中也含有该物质，它对分离的大鼠肾小球旁（ZG）细胞的基础分泌活动或促肾上腺皮质激素刺激的分泌活动均无影响。相反，研究发现NT对ZG细胞对其两种主要的钙依赖性促分泌素——血管紧张素II和钾的醛固酮反应具有强烈的剂量依赖性抑制作用。这些发现表明，NT可能通过减弱细胞溶质钙浓度的升高来干扰血管紧张素II或钾诱导的蛋白激酶C的激活。
