Malendowicz L K, Nussdorfer G G, Majchrzak M, Nowak M, Lesniewska B
Department of Histology and Embryology, University School of Medical Sciences, Poznan, Poland.
In Vivo. 1992 Sep-Oct;6(5):523-5.
Within 2 days neurotensin (NT) and ACTH administrations markedly enhanced the average volume of zona glomerulosa (ZG) cells and plasma aldosterone concentration (PAC) in intact rats. In dexamethasone-treated rats, both NT and ACTH evoked a clearcut ZG-cell hypertrophy, but only NT was able to raise PAC. In conclusion, our findings indicate that NT is a potent stimulator of the growth and secretion of rat ZG in vivo, and suggest that the mechanism underlying this action of NT does not involve the well-known NT-induced stimulation of ACTH release.
