Shinomura Tamayuki
Tokyo Medical and Dental University, Department of Hard Tissue Engineering, Tissue Regeneration.
Clin Calcium. 2006 Mar;16(3):494-8.
Molecular understanding of cartilage differentiation has been improved during the past decade. The finding of Sox9 in particular has improved our understanding of the molecular events during cartilage formation. However, a relatively few transcription factors have been proven to be involved in chondrogenesis. Therefore, the majority of transcription factors and their networks for the differentiation and maturation of chondrocytes may well remain to be elucidated. Here, we summarize the present state of research on transcription factors involved in the differentiation of chondrocytes.
在过去十年中，对软骨分化的分子理解有了改善。特别是Sox9的发现，增进了我们对软骨形成过程中分子事件的理解。然而，相对较少的转录因子已被证明参与软骨形成。因此，软骨细胞分化和成熟的大多数转录因子及其网络很可能仍有待阐明。在此，我们总结了软骨细胞分化相关转录因子的研究现状。
