A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.

作者信息

Dai Jungui, Bai Jiao, Hasegawa Toshiaki, Nishizawa Shigenori, Sakai Junichi, Oka Seiko, Kiuchi Miwa, Hirose Katutoshi, Tomida Akihiro, Tsuruo Takashi, Li Minjie, Ando Masayoshi

机构信息

Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2006 Mar;54(3):306-9. doi: 10.1248/cpb.54.306.

DOI:10.1248/cpb.54.306

PMID:16508182

Abstract

A new taxoid, 5alpha,13alpha-diacetoxy-10beta-cinnamoyloxy-4(20),11-taxadien-9alpha-ol (1) along with its 9,10-isomer, taxinine NN-11 (2) were isolated from the callus cultures of Taxus cuspidata. The structures were identified by the analyses of the spectral data and chemical method. Their in vitro cytotoxicity against 3 cell lines (HepG2, WI-38 and VA-13) and multidrug resistance (MDR) reversal activity toward 2780AD tumor cells were preliminarily evaluated, the low cytotoxicities and potent MDR reversal activities suggested that they might be good lead compounds of tumor MDR reversal agent.

摘要