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NOA小鼠皮肤对金黄色葡萄球菌定植的易感性增加:一种评估抗菌效果的潜在有用动物模型。

Increased susceptibility to Staphylococcus aureus colonization of the skin of the NOA mouse: a potentially useful animal model for evaluating antiseptic effects.

作者信息

Kondo Taizo, Ohno Hitoshi, Taguchi Keisuke, Satode Ryotaro, Kondo Toshio, Shiomoto Yasuhisa

机构信息

Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc., Naruto, Tokushima, Japan

出版信息

Exp Anim. 2006 Jan;55(1):49-56. doi: 10.1538/expanim.55.49.

Abstract

Isolation of bacteria from wet skin lesions was attempted using Naruto Research Institute Otsuka Atrichia (NOA) mice, which develop such lesions spontaneously at a high rate. As a result, Staphylococcus aureus was demonstrated to have colonized the wet skin lesions at high density. In addition, the isolated S. aureus was found to be similar to the strain of S. aureus thought to colonize the eczematous lesions seen in humans with atopic dermatitis. Furthermore, a survey of the S. aureus colonization status of NOA mice with no wet skin lesions confirmed colonization at higher density than in HR-1 mice as control, indicating that the skin of the NOA mouse has the novel characteristic of increased susceptibility to S. aureus colonization. Thus, by using changes in S. aureus counts as an index, the NOA mouse can be expected to serve as a useful animal model for evaluating the effects of topical antiseptics. The antiseptic effects of an ointment and a lotion containing chlorhexidine gluconate were confirmed using this animal model.

摘要

研究人员尝试使用鸣门大冢无毛发研究所(NOA)的小鼠从湿性皮肤损伤处分离细菌,这种小鼠会以较高频率自发出现此类损伤。结果表明,金黄色葡萄球菌在湿性皮肤损伤处大量定植。此外,分离出的金黄色葡萄球菌与被认为定植于特应性皮炎患者湿疹损伤处的金黄色葡萄球菌菌株相似。此外,对没有湿性皮肤损伤的NOA小鼠的金黄色葡萄球菌定植情况进行的调查证实,其定植密度高于作为对照的HR-1小鼠,这表明NOA小鼠的皮肤具有对金黄色葡萄球菌定植易感性增加的新特性。因此,以金黄色葡萄球菌数量的变化为指标,NOA小鼠有望成为评估局部防腐剂效果的有用动物模型。使用该动物模型证实了含有葡萄糖酸洗必泰的软膏和洗剂的防腐效果。

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