Kim Hye Kyung, Kim Mi-Jeong, Shin Dong-Hoon
Department of Food and Biotechnology, Hanseo University, Seosan, Korea.
Ann Nutr Metab. 2006;50(3):277-81. doi: 10.1159/000091686. Epub 2006 Feb 23.
BACKGROUND/AIMS: Lipid disorders may exacerbate some complications of diabetes. Amaranth has been reported to exhibit a cholesterol-lowering effect in hyperlipidemic animals. The present study was designed to investigate the effect of amaranth on serum glucose and the lipid profile in diabetic rats.
Male Sprague-Dawley rats were assigned to normal control, diabetic control, diabetic amaranth-grain (AG)-supplemented (500 g/kg diet) and diabetic amaranth-oil (AO)-supplemented (90 g/kg diet) groups and fed experimental diets for 3 weeks. Effects were monitored on glucose tolerance, serum and liver lipids, and fecal excretions of lipids and bile acids.
Fasting serum glucose levels and the glucose tolerance of diabetic rats were improved by AG and AO supplementation. Serum and liver lipids such as total cholesterol, triglyceride (TG) and very-low-density lipoprotein cholesterol concentrations were also lowered in diabetic animals by AG and AO consumption. Fecal excretions of cholesterol, TG and bile acid were markedly reduced in diabetic rats, and these parameters were dramatically increased by AG and AO supplementation.
AG and AO supplementation improve the glucose and lipid metabolism in streptozotocin-induced diabetic rats.
背景/目的：脂质紊乱可能会加重糖尿病的一些并发症。据报道，苋属植物在高脂血症动物中具有降胆固醇作用。本研究旨在探讨苋属植物对糖尿病大鼠血糖和血脂谱的影响。
将雄性Sprague-Dawley大鼠分为正常对照组、糖尿病对照组、糖尿病苋属谷物（AG）补充组（500克/千克饮食）和糖尿病苋属油（AO）补充组（90克/千克饮食），并给予实验饮食3周。监测对葡萄糖耐量、血清和肝脏脂质以及脂质和胆汁酸粪便排泄的影响。
补充AG和AO可改善糖尿病大鼠的空腹血清葡萄糖水平和葡萄糖耐量。糖尿病动物通过食用AG和AO，血清和肝脏脂质如总胆固醇、甘油三酯（TG）和极低密度脂蛋白胆固醇浓度也降低。糖尿病大鼠粪便中胆固醇、TG和胆汁酸的排泄明显减少，而补充AG和AO后这些参数显著增加。
补充AG和AO可改善链脲佐菌素诱导的糖尿病大鼠的糖脂代谢。
