Ogasa Maki, Nakamura Yasuhiko, Sanai Hiromi, Ueda Kazuyuki
Department of Obstetrics and Gynecology, Yamaguchi Grand Medical Center, Yamaguchi, Japan.
Gynecol Obstet Invest. 2006;62(1):14-6. doi: 10.1159/000091753. Epub 2006 Feb 27.
Hypereosinophilia commonly reflects an allergic, infectious, or neoplastic disease, and is a rare complication during pregnancy.
A 27-year-old pregnant woman was referred to our hospital due to dyspnea at 10 weeks' gestation. Ultrasound examination showed the presence of pericardial effusion, pleural effusion, and ascites. Fluid transfusion, diuretic administration, and oxygen supplementation gradually improved the symptoms. Thereafter, the blood eosinophil count increased acutely and the fetus died. Following cessation of pregnancy the blood eosinophil count gradually decreased. Laboratory examinations did not assist the diagnosis of eosinophilia.
This is the first case of hypereosinophilia associated with the life-threatening hyperpermeability symptoms, i.e., pericardial effusion, pleural effusion, and ascites, during early pregnancy.
嗜酸性粒细胞增多常见于过敏性、感染性或肿瘤性疾病，是孕期罕见的并发症。
一名27岁孕妇在妊娠10周时因呼吸困难转诊至我院。超声检查显示有心包积液、胸腔积液和腹水。输血、使用利尿剂和吸氧后症状逐渐改善。此后，血液嗜酸性粒细胞计数急剧增加，胎儿死亡。终止妊娠后，血液嗜酸性粒细胞计数逐渐下降。实验室检查无助于嗜酸性粒细胞增多症的诊断。
这是首例与危及生命的高通透性症状（即心包积液、胸腔积液和腹水）相关的妊娠早期嗜酸性粒细胞增多病例。
