Kusanagi Y, Ochi H, Matsubara K, Ito M
Department of Obstetrics and Gynecology, Ehime University School of Medicine, Shigenobu, Japan.
Obstet Gynecol. 1998 Oct;92(4 Pt 2):701-2. doi: 10.1016/s0029-7844(98)00084-2.
Hypereosinophilic syndrome is characterized by peripheral blood eosinophilia and multiple organ system involvement. Only one case in a newborn has been reported.
Fetal sonography performed on a 33-year-old woman at 35 weeks' gestation showed pericardial effusion and cardiomegaly. The infant was delivered by cesarean at 35 weeks' gestation because of a worsening of the pericardial effusion. Hematologic studies revealed unexplained hypereosinophilia, and the pericardial fluid contained a large number of eosinophils. Chromosomal analysis revealed trisomy 21. The hypereosinophilia, pericardial effusion, and cardiomegaly all resolved after 8 weeks of steroid therapy.
Hypereosinophilic syndrome caused pericardial effusion and cardiomegaly in a fetus with trisomy 21.
高嗜酸性粒细胞综合征的特征为外周血嗜酸性粒细胞增多及多器官系统受累。仅1例新生儿病例曾有报道。
一名33岁女性在妊娠35周时进行的胎儿超声检查显示心包积液和心脏肿大。由于心包积液恶化，该婴儿于妊娠35周时剖宫产娩出。血液学研究显示存在无法解释的嗜酸性粒细胞增多，心包液中含有大量嗜酸性粒细胞。染色体分析显示21三体。类固醇治疗8周后，嗜酸性粒细胞增多、心包积液和心脏肿大均得到缓解。
高嗜酸性粒细胞综合征在一名21三体胎儿中导致了心包积液和心脏肿大。
