Obara K, Saito T, Sato H, Yamakage K, Watanabe T, Kakizawa M, Tsukamoto T, Kobayashi K, Hongo M, Yoshinaga K
Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Jpn J Med. 1991 Jan-Feb;30(1):67-72. doi: 10.2169/internalmedicine1962.30.67.
We report five patients who have taken inorganic germanium preparations over a prolonged period. In all cases, the renal function deteriorated with no proteinuria or hematuria. Histological examination of the kidneys showed widespread tubular degeneration and interstitial fibrosis with minor glomerular abnormalities. Most patients had gastrointestinal symptoms such as vomiting, anorexia and weight loss; one patient had peripheral neuropathy and myopathy. A considerable amount of germanium was detected in the hair or nails of these patients. These cases clearly show that abuse of inorganic germanium compounds can induce renal damage with various extrarenal manifestations.
我们报告了5例长期服用无机锗制剂的患者。所有病例中，肾功能均恶化，但无蛋白尿或血尿。肾脏组织学检查显示广泛的肾小管变性和间质纤维化，伴有轻微的肾小球异常。大多数患者有胃肠道症状，如呕吐、厌食和体重减轻；1例患者有周围神经病变和肌病。在这些患者的头发或指甲中检测到大量的锗。这些病例清楚地表明，滥用无机锗化合物可导致肾损害并伴有各种肾外表现。
