Henrion D, Chillon J M, Hoffman M, Capdeville-Atkinson C, Atkinson J
Laboratoire de Pharmacologie Cardio-vasculaire, Faculté de Pharmacie, Nancy, France.
Life Sci. 1991;49(8):575-86. doi: 10.1016/0024-3205(91)90256-b.
Treatment of young rats with vitamin D3 plus nicotine, which has been proposed as a model of cardiovascular calcium overload, produced an increase in the calcium content of the mesenteric arterial bed and lowered in vitro vasoconstrictor responses to norepinephrine and serotonin. Attenuation of the vasoconstriction induced by norepinephrine by the endothelium-dependent vasodilators, carbachol and histamine, was diminished, but the effects of sodium nitroprusside and papaverine were unchanged. The vitamin D3 plus nicotine model may be useful for the study of the involvement of calcium overload in vascular endothelial dysfunction.
用维生素D3加尼古丁处理幼鼠（这已被提议作为心血管钙超载的模型），会使肠系膜动脉床的钙含量增加，并降低体外对去甲肾上腺素和5-羟色胺的血管收缩反应。内皮依赖性血管舒张剂卡巴胆碱和组胺对去甲肾上腺素诱导的血管收缩的减弱作用减弱，但硝普钠和罂粟碱的作用未改变。维生素D3加尼古丁模型可能有助于研究钙超载在血管内皮功能障碍中的作用。
