Henrion D, Chillon J M, Godeau G, Muller F, Capdeville-Atkinson C, Hoffman M, Atkinson J
Laboratoire de Pharmacologie Cardio-vasculaire, Université de Nancy I,France.
J Hypertens. 1991 Oct;9(10):919-26.
Treatment of young rats with vitamin D3 plus nicotine has been proposed as a model of cardiovascular calcium overload. This treatment produced a 20-35-fold increase in the calcium content of the aorta, a compliance vessel, and this increase was accompanied by a 1.6-fold elevation of pulse pressure. In aortic rings, the maximal inhibition by the endothelium-dependent vasodilator, carbachol, of vasoconstriction induced by noradrenaline decreased from 90% in controls to 61% in treated animals. There were significant correlations between aortic calcium content and pulse pressure and aortic calcium content and carbachol-induced relaxation. In conclusion, the vitamin D3 plus nicotine model may be useful for the study of the role of calcium overload in decreased arterial compliance coupled with endothelial injury.
用维生素D3加尼古丁处理幼鼠已被提议作为心血管钙超载的一种模型。这种处理使顺应性血管主动脉的钙含量增加了20至35倍，并且这种增加伴随着脉压升高1.6倍。在主动脉环中，内皮依赖性血管舒张剂卡巴胆碱对去甲肾上腺素诱导的血管收缩的最大抑制作用从对照中的90%降至处理动物中的61%。主动脉钙含量与脉压之间以及主动脉钙含量与卡巴胆碱诱导的舒张之间存在显著相关性。总之，维生素D3加尼古丁模型可能有助于研究钙超载在动脉顺应性降低伴内皮损伤中的作用。
