Flugsrud Gunnar B, Nordsletten Lars, Espehaug Birgitte, Havelin Leif I, Engeland Anders, Meyer Haakon E
Oslo Orthopaedic Centre, Ullevål University Hospital, Oslo, Norway.
Arthritis Rheum. 2006 Mar;54(3):802-7. doi: 10.1002/art.21659.
To investigate the effects of body mass index (BMI), height, and age on the risk of later total hip arthroplasty for primary osteoarthritis (OA).
We matched screening data on body height and weight from 1,152,006 persons ages 18-67 years who attended a compulsory screening for tuberculosis in 1963-1975 with data from the Norwegian Arthroplasty Register for the years 1987-2003. We identified 28,425 total hip replacements because of primary OA.
We found dose-response associations between both height and BMI and later hip arthroplasty. The relative risk (RR) among men with a BMI > or = 32 kg/m2 versus a BMI of 20.5-21.9 kg/m2 was 3.4 (95% confidence interval [95% CI] 2.9-4.0). The corresponding RR in women was 2.3 (95% CI 2.1-2.4). There was a decreasing trend in the RR with an increasing age at screening. Among men, the RR for an increase of 5 kg/m2 in the BMI was 2.1 (95% CI 1.7-2.5) when measured at age <25 years and 1.5 (95% CI 1.3-1.7) when measured at ages 55-59 years. Among women, the corresponding RR values were 1.7 (95% CI 1.5-1.9) and 1.1 (95% CI 1.1-1.2).
There was a strong dose-response association between BMI and later total arthroplasty for OA of the hip. Being overweight entailed the highest RR among young participants, and the participants who were overweight at a young age maintained an excess RR for arthroplasty throughout the followup period.
探讨体重指数（BMI）、身高和年龄对原发性骨关节炎（OA）后期全髋关节置换术风险的影响。
我们将1963年至1975年参加结核病强制筛查的1152006名18至67岁人员的身高和体重筛查数据与挪威关节置换登记处1987年至2003年的数据进行匹配。我们确定了28425例因原发性OA进行的全髋关节置换术。
我们发现身高和BMI与后期髋关节置换术之间均存在剂量反应关系。BMI≥32kg/m²的男性与BMI为20.5至21.9kg/m²的男性相比，相对风险（RR）为3.4（95%置信区间[95%CI]2.9至4.0）。女性的相应RR为2.3（95%CI 2.1至2.4）。随着筛查年龄的增加，RR呈下降趋势。在男性中，BMI每增加5kg/m²，<25岁时测量的RR为2.1（95%CI 1.7至2.5），55至59岁时测量的RR为1.5（95%CI 1.3至1.7）。在女性中，相应的RR值分别为1.7（95%CI 1.5至1.9）和1.1（95%CI 1.1至1.2）。
BMI与后期髋关节OA全关节置换术之间存在强烈的剂量反应关系。超重者在年轻参与者中RR最高，且年轻时超重的参与者在整个随访期间关节置换术的RR一直过高。
