Meyer H E, Tverdal A, Falch J A
National Health Screening Service, Aker Hospital, Oslo, Norway.
Epidemiology. 1995 May;6(3):299-305.
We studied the relations between body height, body mass index (BMI), and fatal hip fractures prospectively in a large, representative population. During the years 1963-1975, a nationwide compulsory mass x-ray examination including standardized height and weight measurements took place in Norway covering all persons age 15 years and older. In the study presented here, we selected women (N = 357,807) and men (N = 316,041) age 50-89 years at screening. We matched the file to the national death register containing causes of death throughout 1991; we defined cases as persons with hip fracture mentioned on their death certificates. During an average follow-up of 16.4 years, we identified a total of 6,087 fatal hip fractures in the study population. There was a distinct inverse relation between BMI and fatal hip fracture, with an age-adjusted relative risk (RR) in the three highest vs the low quartile of 0.68 [95% confidence interval (CI) = 0.63-0.72] in women and 0.57 (95% CI = 0.52-0.62) in men. The risk of fatal hip fractures increased slightly with increasing body height [RR = 1.10 (95% CI = 1.04-1.16) in women and RR = 1.08 (95% CI = 1.01-1.16) in men per 10-cm increase in body height]. This study indicates that low BMI is an important risk factor for fatal hip fractures and that body height has a weak, positive association.
我们在一个大型代表性人群中对身高、体重指数(BMI)与致命性髋部骨折之间的关系进行了前瞻性研究。1963年至1975年期间,挪威开展了一项全国性强制大规模X光检查,包括标准化身高和体重测量,涵盖所有15岁及以上人群。在本研究中,我们选取了筛查时年龄在50 - 89岁的女性(N = 357,807)和男性(N = 316,041)。我们将该档案与包含1991年全年死亡原因的国家死亡登记册进行匹配;我们将病例定义为死亡证明上提及髋部骨折的人。在平均16.4年的随访期间,我们在研究人群中总共确定了6,087例致命性髋部骨折。BMI与致命性髋部骨折之间存在明显的负相关,在女性中,三个最高四分位数与最低四分位数相比,年龄调整后的相对风险(RR)为0.68 [95%置信区间(CI)= 0.63 - 0.72],在男性中为0.57(95% CI = 0.52 - 0.62)。致命性髋部骨折的风险随身高增加略有增加[女性每身高增加10厘米,RR = 1.10(95% CI = 1.04 - 1.16),男性RR = 1.08(95% CI = 1.01 - 1.16)]。这项研究表明,低BMI是致命性髋部骨折的一个重要风险因素,而身高与之有较弱的正相关。