辐射和烷化剂对正常及肿瘤淋巴细胞中染色质降解的影响。
The effects of radiation and alkylating agents on chromatin degradation in normal and tumour lymphoid cells.
作者信息
Ryabchenko N I, Jurásková V, Ivannik B P, Konov A V, Drásil V
机构信息
Research Institute of Medical Radiology, Academy of Medical Sciences of the USSR, Obninsk.
出版信息
Gen Physiol Biophys. 1991 Feb;10(1):41-8.
The dynamic of chromatin degradation was studied in thymocytes and LS/BL tumour cells. In permeabilised LS/BL cells, the rate of DNA degradation induced by endogenous calcium and magnesium-dependent endonuclease was approx. 25 times slower than in thymocytes. In LS/BL cells irradiation does not induce chromatin degradation. The alkylating agent TS 160 induced chromatin degradation in both LS/BL lymphosarcoma cells and thymocytes.
在胸腺细胞和LS/BL肿瘤细胞中研究了染色质降解的动态过程。在经通透处理的LS/BL细胞中，内源性钙和镁依赖性核酸内切酶诱导的DNA降解速率比胸腺细胞中慢约25倍。在LS/BL细胞中，辐射不会诱导染色质降解。烷化剂TS 160在LS/BL淋巴肉瘤细胞和胸腺细胞中均诱导染色质降解。
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