Soldatenkov V A, Sorokina N I, Filippovich I V
Radiobiologiia. 1985 May-Jun;25(3):300-3.
Chemical inductors of differentiation were shown to cause chromatin degradation in thymus lymphocytes. This process was prevented by the protein synthesis inhibitors. The fragments formed after the effect of chemical differentiation inductors on thymocytes were fully identical to chromatin internucleosome degradation products formed in the exposed cells. Chromatin degradation under the effect of chemical differentiation inductors was most pronounced in a more radiosensitive thymocyte fraction.
已表明分化的化学诱导剂可导致胸腺淋巴细胞中的染色质降解。该过程可被蛋白质合成抑制剂阻止。化学分化诱导剂作用于胸腺细胞后形成的片段与暴露细胞中形成的染色质核小体间降解产物完全相同。在对辐射更敏感的胸腺细胞组分中，化学分化诱导剂作用下的染色质降解最为明显。
