Martínez-González Miguel Angel
Department of Preventive Medicine and Public Health, Universidad de Navarra, Pamplona, Spain.
Public Health Nutr. 2006 Feb;9(1A):127-31. doi: 10.1079/phn2005935.
Cohort study (the SUN project) to identify dietary determinants of hypertension, diabetes, obesity and coronary heart disease (CHD), among other conditions.
The SUN project is a Mediterranean dynamic prospective follow-up (cohort) study assessing participants every 2 years. The recruitment started in 2000 and it is permanently open (this is a dynamic cohort). A preliminary case-control study of myocardial infarction was also conducted, selecting incident cases of myocardial infarction and matched hospital controls.
The SUN study is conducted in Spain with university graduates, most of them being former students of the University of Navarra. The case-control study was conducted in three tertiary hospitals in the city of Pamplona (Spain).
The case-control study included 171 cases and 171 controls. We have currently enrolled more than 17,500 participants in the SUN cohort. Approximately 7500 of them were enrolled less than 2 years ago, and have not received yet the invitation to complete the 2-year follow-up assessment. The follow-up rate for the first 10,000 participants approaches 90%.
The case-control study found inverse associations between olive oil (or adherence to a Mediterranean food pattern) and myocardial infarction. In the SUN cohort, after 28.5 months of follow-up a higher adherence to a Mediterranean food pattern rich in olive oil was associated with a reduced risk of hypertension, though the results were statistically significant only among men.
The SUN study and the accompanying case-control study support the benefits of a Mediterranean diet and olive oil against CHD and hypertension.
队列研究（SUN项目），以确定高血压、糖尿病、肥胖症和冠心病（CHD）等疾病的饮食决定因素。
SUN项目是一项地中海动态前瞻性随访（队列）研究，每两年对参与者进行评估。招募工作始于2000年，且永久开放（这是一个动态队列）。还进行了一项心肌梗死的初步病例对照研究，选取心肌梗死的新发病例和匹配的医院对照。
SUN研究在西班牙针对大学毕业生开展，其中大多数是纳瓦拉大学的往届学生。病例对照研究在西班牙潘普洛纳市的三家三级医院进行。
病例对照研究包括171例病例和171名对照。目前，SUN队列已招募了超过17500名参与者。其中约7500人是在不到两年前招募的，尚未收到完成两年随访评估的邀请。前10000名参与者的随访率接近90%。
病例对照研究发现橄榄油（或坚持地中海饮食模式）与心肌梗死之间存在负相关。在SUN队列中，经过28.5个月的随访，坚持富含橄榄油的地中海饮食模式与高血压风险降低相关，不过该结果仅在男性中具有统计学意义。
SUN研究及相关病例对照研究支持地中海饮食和橄榄油对冠心病和高血压的益处。
