没有证据表明内侧颞叶结构在高功能自闭症中存在优先受累情况。
No evidence for preferential involvement of medial temporal lobe structures in high-functioning autism.
作者信息
Palmen Saskia J M C, Durston Sarah, Nederveen Hilde, Van Engeland Herman
机构信息
Rudolf Magnus Institute of Neuroscience, Department of Child, University Medical Center Utrecht, Utrecht, The Netherlands.
出版信息
Psychol Med. 2006 Jun;36(6):827-34. doi: 10.1017/S0033291706007215. Epub 2006 Mar 2.
BACKGROUND
Autism is a neurodevelopmental disorder associated with slight increases in brain volume. There has been some suggestion that medial temporal lobe structures may be preferentially involved in this disorder, although results have not always been consistent. Here, we investigate amygdala and hippocampus volumes in medication-naive subjects with high-functioning autism.
METHOD
Whole-brain magnetic resonance imaging scans were acquired from 42 patients and 42 closely matched, healthy control subjects.
RESULTS
Amygdala volume did not differ significantly between patients and controls. A significant increase in hippocampal volume was proportional to an increase in overall brain volume.
CONCLUSIONS
These results argue against preferential involvement of medial temporal lobe structures in autism, at least in high-functioning medication-naive individuals.
背景
自闭症是一种与脑容量略有增加相关的神经发育障碍。尽管结果并不总是一致，但有一些迹象表明内侧颞叶结构可能在这种疾病中受到优先影响。在此，我们研究了未接受过药物治疗的高功能自闭症患者的杏仁核和海马体体积。
方法
对42名患者和42名年龄、性别匹配的健康对照者进行了全脑磁共振成像扫描。
结果
患者与对照组之间的杏仁核体积无显著差异。海马体体积的显著增加与全脑体积的增加成正比。
结论
这些结果表明，至少在未接受过药物治疗的高功能个体中，内侧颞叶结构并非优先受累于自闭症。
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