Warriner Erin M, Velikonja Diana
McMaster University Medical Centre, Room 3G-30, Hamilton Health Sciences, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada.
Curr Psychiatry Rep. 2006 Feb;8(1):73-80. doi: 10.1007/s11920-006-0083-2.
Traumatic brain injuries (TBI) are frequently accompanied by psychiatric disturbances, which can include striking to relatively minor alterations in personality, behavior, and emotional regulation. The persistence of these neurobehavioral syndromes often leads to deleterious effects on recovery and rehabilitation outcomes. A recent surge of studies has emerged in the past several years to quantify the extent of psychiatric disorders in TBI and to describe differential clinical presentations. Various pre- and post-injury factors also have been hypothesized to contribute to the development and maintenance of psychiatric symptoms in survivors of brain injuries. The identification of high-risk individuals with distinct neuropathophysiological and psychosocial features permits the development of multidisciplinary and tailored approaches to the assessment, prevention, and management of the negative effects of personality and behavioral changes in TBI. This article summarizes the most recent research in these areas and highlights the gaps that need to be filled in subsequent future.
创伤性脑损伤（TBI）常伴有精神障碍，包括从显著变化到相对轻微的人格、行为和情绪调节改变。这些神经行为综合征的持续存在往往会对康复和恢复结果产生有害影响。在过去几年中，涌现出了大量研究，旨在量化TBI中精神障碍的程度，并描述不同的临床表现。各种伤前和伤后因素也被认为与脑损伤幸存者精神症状的发生和持续存在有关。识别具有独特神经病理生理和社会心理特征的高危个体，有助于制定多学科且量身定制的方法，以评估、预防和管理TBI中人格和行为变化带来的负面影响。本文总结了这些领域的最新研究，并突出了后续需要填补的空白。
