Stuhmiller James H, Long Diane W, Stuhmiller Louise M
Simulation, Engineering, and Test Group, Applied Technologies, L-3 Communications, San Diego, California, USA.
Inhal Toxicol. 2006 May;18(5):347-64. doi: 10.1080/08958370500516010.
A mathematical model for estimating the likelihood of incapacitation and lethality from the inhalation of toxic gases is presented. The model computes an internal dose, equal to retained toxic gas per body mass, which is used to extrapolate outcomes across species. Account is taken for ventilation changes due to species, activity, and chemical response. The internal dose is correlated with each outcome using a cumulative, log-normal, probability distribution, which allows the estimation of tolerances for any population incidence. No internal interactions of gases are modeled and probabilities are combined independently. The model compares favorably with combined gas and large animal data.
提出了一种用于估计吸入有毒气体导致失能和致死可能性的数学模型。该模型计算一个内部剂量，等于每单位体重留存的有毒气体量，用于推断不同物种的结果。考虑了因物种、活动和化学反应导致的通气变化。使用累积对数正态概率分布将内部剂量与每个结果相关联，从而能够估计任何人群发病率的耐受性。未对气体的内部相互作用进行建模，概率是独立组合的。该模型与混合气体和大型动物数据相比表现良好。
