Stuhmiller James H, Stuhmiller Louise M
Simulation, Engineering, and Testing Group, Jaycor, Inc., San Diego, California, USA.
Inhal Toxicol. 2002 Sep;14(9):929-57. doi: 10.1080/08958370290084700.
A quantitative mathematical model assesses incapacitation risk in humans from toxic gas inhalation. A body-mass-normalized internal dose for each gas is calculated from an inhalation equation in which ventilation is a function of species, activity, and the gases inhaled. Uptake in the dead space considers U.S. Environmental Protection Agency (EPA) gas categories. The probability of incapacitation is a function of normalized internal dose and follows a cumulative distribution curve whose parameters are found from small-animal incapacitation data. No internal interaction of gases is modeled, and probabilities are combined independently. The model compares favorably with combined gas and large-animal incapacitation data.
