呼吸机相关性肺炎：趋向短疗程治疗
Ventilator-associated pneumonia: gearing towards shorter-course therapy.
作者信息
Chua Thea de Jesus, File Thomas M
机构信息
Summa Health System, 75 Arch Street, Akron, OH 44304, USA.
出版信息
Curr Opin Infect Dis. 2006 Apr;19(2):185-8. doi: 10.1097/01.qco.0000216630.59186.9e.
PURPOSE OF REVIEW
The studies that are reviewed in this article have all concluded that a shorter duration of antibiotic therapy (7-8 days) may be adequate in the treatment of the majority of patients with ventilator-associated pneumonia, and does not confer an increased incidence of mortality.
RECENT FINDINGS
Ventilator-associated pneumonia has traditionally been treated with at least 2 weeks of antimicrobial therapy. With the increasing emergence of multi-drug-resistant pathogens, however, efforts have been directed at minimizing the duration of therapy. Several studies have emerged over the last few years aiming to shorten the duration of antimicrobial therapy for ventilator-associated pneumonia.
SUMMARY
The minimum effective duration of antibiotic therapy, however, remains unclear. Further studies geared towards determining this are needed.
综述目的
本文所综述的研究均得出结论，较短疗程（7 - 8天）的抗生素治疗可能足以治疗大多数呼吸机相关性肺炎患者，且不会增加死亡率。
最新发现
传统上，呼吸机相关性肺炎采用至少2周的抗菌治疗。然而，随着多重耐药病原体的日益出现，人们致力于尽量缩短治疗疗程。过去几年出现了几项旨在缩短呼吸机相关性肺炎抗菌治疗疗程的研究。
总结
然而，抗生素治疗的最短有效疗程仍不明确。需要开展进一步研究来确定这一点。
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