Giordano G, Gnetti L, Ricci R, Merisio C, Melpignano M
Department of Pathology, Section of Pathology, Parma University, Parma, Italy.
Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:433-8. doi: 10.1111/j.1525-1438.2006.00235.x.
The aim of this study was to elucidate the clinicopathologic features, the differential diagnostic problems, and the prognostic consequences of patients with metastatic extragenital malignancies to uterus. The patients with metastatic extragenital malignancies to the uterus were evaluated. We considered the metastases in non-genital tract organs at diagnosis of primary neoplasm, the distribution of the metastases in the uterus, and the presence of concomitant metastases in other genital and non-genital tract organs. There were four cases of metastatic extragenital malignancies to the uterus. The breast was the most frequent primary site (two cases: 50%). The other two primary tumors were adenocarcinoma of the cecum and malignant melanoma of the skin. The diagnosis was facilitated by clinical history, revealing the previous primary neoplasm, and by specific immunohistochemical study. Almost all the patients died from disseminated disease. Thus, the prognosis of metastatic extragenital malignancies to the uterus alone or simultaneously to the uterus and other organs of the genital tract is poor. Thus, the metastases to the uterus and to other organs of the genital tract can be considered a preterminal event.
本研究的目的是阐明子宫转移性非生殖系统恶性肿瘤患者的临床病理特征、鉴别诊断问题及预后情况。对子宫转移性非生殖系统恶性肿瘤患者进行了评估。我们考虑了原发性肿瘤诊断时非生殖道器官的转移情况、子宫内转移灶的分布以及其他生殖和非生殖道器官中伴随转移灶的存在情况。有4例子宫转移性非生殖系统恶性肿瘤。乳腺是最常见的原发部位（2例，占50%）。另外两例原发性肿瘤分别为盲肠腺癌和皮肤恶性黑色素瘤。通过临床病史（揭示先前的原发性肿瘤）和特异性免疫组化研究有助于做出诊断。几乎所有患者均死于播散性疾病。因此，子宫单独发生转移性非生殖系统恶性肿瘤或同时伴有子宫及生殖道其他器官转移的预后较差。因此，子宫及生殖道其他器官的转移可被视为临终前事件。
