Mukaratirwa Sydney, Chikafa Lynne, Dliwayo Rachel, Moyo Ndumiso
Department of Paraclinical Studies, Pathology Section, Faculty of Veterinary Science, University of Zimbabwe, PO Box MP 167, Mount Pleasant, Harare, Zimbabwe.
Vet Dermatol. 2006 Apr;17(2):141-6. doi: 10.1111/j.1365-3164.2006.00505.x.
The biological significance of mast cells and angiogenesis in canine melanomas is unclear. Eighty canine melanomas (56 malignant and 24 benign), investigated to determine the relationship between mast cell count (MCC), microvessel density (MVD) and clinicopathology, revealed significantly higher MCC and MVD counts in malignant melanomas. Evaluation of the prognostic significance of MCC and MVD in malignant melanomas showed a significant correlation between MCC and MVD both within and at the edges of the tumour. Multivariate analysis indicated that MCC and MVD were independent predictors of survival but the former was a significantly better prognostic marker. Greater numbers of mast cells and microvessels were found in malignant melanomas of poor prognosis. The findings demonstrate a prognostic significance of MCC and MVD in canine melanocytic tumours.
肥大细胞和血管生成在犬黑色素瘤中的生物学意义尚不清楚。对80例犬黑色素瘤（56例恶性和24例良性）进行研究，以确定肥大细胞计数（MCC）、微血管密度（MVD）与临床病理学之间的关系，结果显示恶性黑色素瘤中的MCC和MVD计数显著更高。对恶性黑色素瘤中MCC和MVD的预后意义评估表明，肿瘤内部和边缘的MCC与MVD之间存在显著相关性。多变量分析表明，MCC和MVD是生存的独立预测因子，但前者是一个显著更好的预后标志物。预后较差的恶性黑色素瘤中发现了更多的肥大细胞和微血管。这些发现证明了MCC和MVD在犬黑素细胞肿瘤中的预后意义。
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