Holland-Cunz Stefan, Göppl Max, Rauch Ulrich, Bär Claudia, Klotz Markus, Schäfer Karl-Herbert
Department of Pediatric Surgery, University of Heidelberg, 69120 Heidelberg, Germany.
J Pediatr Surg. 2006 Mar;41(3):e29-31. doi: 10.1016/j.jpedsurg.2005.12.060.
In this report, we present the first case of an immunologically impaired child surviving a lytic varicella-zoster virus infection affecting the enteric nervous system. In histological findings, myenteric and submucous enteric ganglia were nearly completely absent owing to virus infection.
A 3-year-old girl with acute lymphoblastic leukemia and generalized varicella-zoster infection developed an ileus. She underwent multiple laparotomies in which histological sections of the entire small intestine could be obtained.
The histological evaluation of these samples showed a generalized aganglionosis with inflammatory residuals. A more detailed immunohistochemical analysis using neuronal (PGP, enolase), glial (S100), and lymphocytic (LCA) antibodies demonstrated a nearly complete neuronal loss.
To our knowledge, this is the first case of a secondary intestinal aganglionosis after varicella-zoster virus infection.
在本报告中，我们呈现了首例免疫功能受损儿童在感染溶细胞性水痘-带状疱疹病毒并累及肠神经系统后存活的病例。在组织学检查结果中，由于病毒感染，肌间和黏膜下肠神经节几乎完全缺失。
一名患有急性淋巴细胞白血病且发生全身性水痘-带状疱疹感染的3岁女孩出现肠梗阻。她接受了多次剖腹手术，术中获取了整个小肠的组织切片。
对这些样本的组织学评估显示为广泛性无神经节症伴炎症残留。使用神经元（PGP、烯醇化酶）、神经胶质（S100）和淋巴细胞（LCA）抗体进行的更详细免疫组织化学分析显示神经元几乎完全丧失。
据我们所知，这是水痘-带状疱疹病毒感染后继发性肠道无神经节症的首例病例。
