心力衰竭患者中B型利钠肽与6分钟步行试验的相关性

Correlates of B-type natriuretic peptide and 6-min walk in heart failure patients.

作者信息

Hogenhuis Jochem, Jaarsma Tiny, Voors Adriaan A, Hillege Hans L, Lesman Ivonne, van Veldhuisen Dirk J

机构信息

Department of Cardiology, Thoraxcenter, University Medical Center Groningen, PO Box 30.001, Groningen 9700 RB, The Netherlands.

出版信息

Int J Cardiol. 2006 Mar 22;108(1):63-7. doi: 10.1016/j.ijcard.2005.04.007.

DOI:10.1016/j.ijcard.2005.04.007

PMID:16516699

Abstract

BACKGROUND

B-type natriuretic peptide (BNP) and 6-min walk test (6MWT) are both related to the severity and prognosis in chronic heart failure (CHF), but may reflect different aspects of CHF. We related BNP and 6MWT to left ventricular ejection fraction (LVEF), New York Heart Association functional class (NYHA), and two indices of quality of life (physical subscales): the Minnesota Living with Heart Failure Questionnaire (MLwHFQph) and the RAND-36ph.

METHODS

Plasma BNP and 6MWT were measured at discharge in 229 patients who had been admitted for CHF. LVEF and NYHA were determined, and patients completed the MLwHFQ and RAND-36 questionnaires.

RESULTS

BNP was weakly correlated to LVEF (r=-0.29, P<0.01) and NYHA (r=0.20, P<0.01), but not to MLwHFQph and RAND-36ph. On the other hand, 6MWT is related to MLwHFQph (r=-0.23, P<0.01), RAND-36ph (r=0.52, P<0.01), and NYHA (r=-0.46, P<0.01), but not to LVEF (r=-0.15, P=0.05). There is also no correlation between BNP and 6MWT (r=-0.01, P=0.87).

CONCLUSIONS

The present data show that BNP and 6MWT represent different aspects of the clinical syndrome of CHF. The outcomes of this study suggest that BNP plasma levels are more related to cardiac function, while 6MWT reflects functional capacity and quality of life.

摘要

背景

B型利钠肽（BNP）和6分钟步行试验（6MWT）均与慢性心力衰竭（CHF）的严重程度及预后相关，但可能反映CHF的不同方面。我们将BNP和6MWT与左心室射血分数（LVEF）、纽约心脏协会功能分级（NYHA）以及两个生活质量指标（身体分量表）：明尼苏达心力衰竭生活问卷（MLwHFQph）和RAND-36身体分量表进行关联分析。

方法

对229例因CHF入院的患者在出院时测定血浆BNP和进行6MWT。测定LVEF和NYHA，并让患者完成MLwHFQ和RAND-36问卷。

结果

BNP与LVEF（r = -0.29，P < 0.01）和NYHA（r = 0.20，P < 0.01）呈弱相关，但与MLwHFQph和RAND-36ph无相关性。另一方面，6MWT与MLwHFQph（r = -0.23，P < 0.01）、RAND-36ph（r = 0.52，P < 0.01）和NYHA（r = -0.46，P < 0.01）相关，但与LVEF无相关性（r = -0.15，P = 0.05）。BNP与6MWT之间也无相关性（r = -0.01，P = 0.87）。