Transmitter regulation of voltage-dependent K+ channels expressed in Xenopus oocytes.
作者信息
Kavanaugh M P, Christie M J, Osborne P B, Busch A E, Shen K Z, Wu Y N, Seeburg P H, Adelman J P, North R A
机构信息
Vollum Institute, Oregon Health Sciences University, Portland 97201.
出版信息
Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):899-902. doi: 10.1042/bj2770899.
Abstract
Voltage-dependent K+ channels (RBK1, RBK2 and RGK5) were co-expressed in Xenopus oocytes with 5-hydroxytryptamine (5-HT2) receptors. K+ currents measured 2-4 days later were inhibited by 5-HT (100 nM-10 microM, 20-30 s application) by up to 90%. The effect of 5-HT was mimicked by intracellular injection of Ins(1,4,5)P3. Increasing the Ca2+ concentration at the inner surface of excised membrane patches did not decrease the K+ current.
摘要
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