Chu C L, Xue X Y, Zhu J C, Yin Z D
Department of Materials Science and Engineering, Southeast University, Nanjing 210018, China.
Biomed Mater Eng. 2006;16(3):203-13.
Biocompatibility and bonding strength of hydroxyapatite-20vol%Ti composite fabricated by hot-pressing technique with bone tissues in the rabbit were investigated by in vivo studies in comparison with those of Ti metal and dense HA ceramic. Although fibrous tissues formed at the interface between the composite and bone tissues at 3 weeks in vivo, bonding strength of the composite increases faster than that of dense HA after 4 weeks. At 3 months in vivo, bonding strength of the composite is higher than that of dense HA and exceeds 6.5 MPa. Moreover, as compared with the visible bonding interfaces between dense HA and new bones, the bonding interfaces for the composite cannot already be distinguished and the composite was osseointegrated fully with bone tissues into one bony body. The shear fracture of bonding strength test for the composite occurred in new bone zones near the interface, which indicates that bonding strength of the composite could even exceed the shear strength of new bones after 3 months in vivo. In conclusion, HA-Ti composite has better osteoconduction and osseointegration abilities than Ti metal and dense HA ceramic after 3 months in vivo and is a promising biomaterial for hard tissue replacement.
通过体内研究，对比钛金属和致密羟基磷灰石（HA）陶瓷，对采用热压技术制备的含20%体积分数钛的羟基磷灰石复合材料与兔骨组织的生物相容性和结合强度进行了研究。尽管在体内3周时复合材料与骨组织界面处形成了纤维组织，但4周后复合材料的结合强度比致密HA增长得更快。在体内3个月时，复合材料的结合强度高于致密HA，超过6.5MPa。此外，与致密HA和新骨之间明显的结合界面相比，复合材料的结合界面已无法区分，复合材料与骨组织完全骨整合为一个骨质体。复合材料结合强度测试的剪切断裂发生在界面附近的新骨区域，这表明在体内3个月后复合材料的结合强度甚至可能超过新骨的剪切强度。总之，在体内3个月后，HA-Ti复合材料比钛金属和致密HA陶瓷具有更好的骨传导性和骨整合能力，是一种有前景的硬组织替代生物材料。
