Iseri Pervin K, Altinaş Ozgül, Tokay Tomris, Yüksel Nurşen
Department of Neurology, Kocaeli University Medical School, Kocaeli, Turkey.
J Neuroophthalmol. 2006 Mar;26(1):18-24. doi: 10.1097/01.wno.0000204645.56873.26.
There is conflicting evidence as to whether Alzheimer disease (AD) is accompanied by loss of retinal ganglion cells. To evaluate this issue, we have used optical coherence tomography (OCT) to assess the thickness and volume of the retina. We have also sought to correlate our findings with visual function and cognitive impairment.
We evaluated 28 eyes of 14 patients with AD and 30 eyes of 15 age-matched control subjects. In these two groups, we measured retinal nerve fiber layer (RNFL) thickness, macular thickness, and macular volume with OCT, visual function through latency of the pattern visual evoked potential (VEP) signal, and cognitive impairment through the Mini-Mental State Examination (MMSE).
The parapapillary and macular RNFL thickness in all quadrants and positions of AD patients were thinner than in control subjects. The mean total macular volume of AD patients was significantly reduced as compared with control subjects (P < 0.05). Total macular volume and MMSE scores were significantly correlated. No significant difference was found in the latency of the VEP P100 of AD patients and control subjects.
Our study confirms some other studies in showing that in AD patients there is a reduction of parapapillary and macular RNFL thickness and macular volume as measured by OCT. The reduction in macular volume was related to the severity of cognitive impairment.
关于阿尔茨海默病（AD）是否伴有视网膜神经节细胞丢失，证据存在冲突。为评估此问题，我们使用光学相干断层扫描（OCT）来评估视网膜的厚度和体积。我们还试图将我们的发现与视觉功能和认知障碍相关联。
我们评估了14例AD患者的28只眼和15名年龄匹配的对照受试者的30只眼。在这两组中，我们用OCT测量视网膜神经纤维层（RNFL）厚度、黄斑厚度和黄斑体积，通过图形视觉诱发电位（VEP）信号的潜伏期评估视觉功能，通过简易精神状态检查表（MMSE）评估认知障碍。
AD患者所有象限和位置的视乳头旁和黄斑RNFL厚度均比对照受试者薄。与对照受试者相比，AD患者的平均黄斑总体积显著降低（P < 0.05）。黄斑总体积与MMSE评分显著相关。AD患者和对照受试者的VEP P100潜伏期未发现显著差异。
我们的研究与其他一些研究一致，表明通过OCT测量，AD患者视乳头旁和黄斑RNFL厚度以及黄斑体积减小。黄斑体积减小与认知障碍的严重程度相关。
