Jacobsen D W
Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Kidney Int. 2006 Mar;69(5):787-9. doi: 10.1038/sj.ki.5000235.
Hyperhomocysteinemia, an independent, modifiable risk factor for cardiovascular disease, is found in most patients with end-stage renal disease. In this issue, Perna et al. examine the extent of protein-S-linked and protein-N-linked homocysteinylation in uremic patients on hemodialysis and the effect of folate treatment on protein homocysteinylation. Their findings show that protein-N-linked homocysteinylation, but not S-linked homocysteinylation, can be normalized by folate therapy.
高同型半胱氨酸血症是心血管疾病的一个独立且可改变的危险因素，在大多数终末期肾病患者中都有发现。在本期杂志中，佩尔纳等人研究了接受血液透析的尿毒症患者中蛋白质 - S连接型和蛋白质 - N连接型同型半胱氨酸化的程度，以及叶酸治疗对蛋白质同型半胱氨酸化的影响。他们的研究结果表明，叶酸治疗可使蛋白质 - N连接型同型半胱氨酸化恢复正常，但不能使蛋白质 - S连接型同型半胱氨酸化恢复正常。
