Ceyhan Temel, Beyan Cengiz, Başer Iskender, Kaptan Kürşat, Güngör Sadettin, Ifran Ahmet
Departments of Obstetric and Gynecology, Gulhane Military Medical Academy, Ankara, Turkey.
Ann Hematol. 2006 May;85(5):320-2. doi: 10.1007/s00277-006-0091-7. Epub 2006 Mar 4.
Pre-eclampsia is a condition observed during pregnancy and threatens the life of both mother and foetus. There are studies, which suggest platelets play a major role in the pathogenesis of pre-eclampsia. The aim of this study is to compare the complete blood count (CBC) parameters, especially platelet count and mean platelet volume (MPV), in pre-eclamptic and normal pregnant women and to evaluate whether these parameters have a prognostic significance in determining the severity of eclampsia. The study and control groups consist of 56 pre-eclamptic and 43 normal pregnant women, respectively. There was no statistically significant difference according to CBC, platelet count and MPV when pre-eclamptic and severely pre-eclamptic patients were compared with controls. As a result, we observed no prognostic significance of CBC, platelet count and MPV on the presence and/or severity of pre-eclamptic condition. There are conflicting results especially on the significance of MPV in the literature, and possibly this confliction is due to the difference between methods and/or equipments used for automated blood count.
子痫前期是孕期出现的一种病症，会危及母亲和胎儿的生命。有研究表明，血小板在子痫前期的发病机制中起主要作用。本研究的目的是比较子痫前期孕妇和正常孕妇的全血细胞计数（CBC）参数，尤其是血小板计数和平均血小板体积（MPV），并评估这些参数在确定子痫严重程度方面是否具有预后意义。研究组和对照组分别由56名单纯子痫前期孕妇和43名正常孕妇组成。将单纯子痫前期患者和重度子痫前期患者与对照组进行比较时，根据全血细胞计数、血小板计数和平均血小板体积，未发现有统计学意义的差异。结果，我们观察到全血细胞计数、血小板计数和平均血小板体积对子痫前期病症的存在和/或严重程度没有预后意义。尤其是关于平均血小板体积在文献中的意义，存在相互矛盾的结果，这种矛盾可能是由于自动血细胞计数所使用的方法和/或设备不同所致。
