Akcan A B, Oygucu Seyhan E, Ozel Deniz, Oygür Nihal
Division of Neonatology, Department of Pediatrics, School of Medicine, Akdeniz University, Antalya, Turkey.
Blood Coagul Fibrinolysis. 2011 Jun;22(4):285-7. doi: 10.1097/MBC.0b013e3283451267.
The aim of this study was to compare the mean platelet volume (MPV) in babies of preeclamptic and normal pregnant women and to investigate the correlation between thrombocytopenia and MPV in the babies of preeclamptic mothers. A total of 63 newborns with similar gestational ages were included in this retrospective study. They were divided into three groups as 21 babies of preeclamptic mothers with thrombocytopenia (Group A), 21 without thrombocytopenia (Group B), and 21 babies of normal pregnant women without thrombocytopenia (Group C). Hematologic data of these patients, obtained in the first 72 h of their life, were obtained from their medical records. Groups were compared according to their birth weights, platelet counts, and MPV. Gestational ages and birth weights of all groups were similar. The platelet count of group A was significantly lower (P < 0.001). MPV seemed to increase as platelet counts decreased when the groups were compared. However, no significant correlation was found between MPV and platelet counts and no significant difference between MPVs (P = 0.052). Increase in MPV is accepted as a sign of platelet destruction and decrease as a sign of platelet production insufficiency. Our results showed that the cause of thrombocytopenia in babies of preeclamptic mothers cannot be explained with the help of MPV.
本研究旨在比较子痫前期孕妇和正常孕妇所生婴儿的平均血小板体积（MPV），并探讨子痫前期母亲所生婴儿血小板减少与MPV之间的相关性。本回顾性研究共纳入63例孕周相似的新生儿。他们被分为三组，21例为子痫前期母亲所生且有血小板减少的婴儿（A组），21例无血小板减少的（B组），以及21例正常孕妇所生无血小板减少的婴儿（C组）。这些患者出生后72小时内的血液学数据来自其病历。根据出生体重、血小板计数和MPV对各组进行比较。所有组的孕周和出生体重相似。A组的血小板计数显著更低（P < 0.001）。比较各组时，血小板计数降低时MPV似乎升高。然而，未发现MPV与血小板计数之间存在显著相关性，且MPV之间无显著差异（P = 0.052）。MPV升高被认为是血小板破坏的标志，降低是血小板生成不足的标志。我们的结果表明，子痫前期母亲所生婴儿血小板减少的原因无法用MPV来解释。
